Table 2.
Incidence (by number of patients) and grade of treatment-related toxicities experienced during the first two cycles and at any time during treatment.
| Toxicity (experienced by >10% of patients) |
During Cycles 1 or 2 | At Any Time | ||
|---|---|---|---|---|
| Grade 1/2 |
Grade 3 | Grade 1/2 |
Grade 3 | |
| DERMATOLOGY/SKIN | ||||
| Rash | ||||
| acne/acneiform | 11 | 1* | 13 | 2 |
| hand-foot skin reaction | 6 | 0 | 6 | 1 |
| desquamation | 0 | 0 | 2 | 1 |
| dry skin | 0 | 0 | 3 | 0 |
| Pruritus/itching | 0 | 0 | 2 | 1 |
| Mucositis/stomatitis: oral cavity | 3 | 0 | 5 | 0 |
| GASTROINTESTINAL | ||||
| Diarrhea | 7 | 1* | 10 | 1 |
| Nausea | 6 | 0 | 7 | 0 |
| Vomiting | 3 | 0 | 4 | 0 |
| CONSTITUTIONAL | ||||
| Fatigue | 5 | 0 | 5 | 1 |
| Anorexia | 3 | 0 | 4 | 0 |
| Pain | 0 | 0 | 2 | 1 |
| HEMATOLOGIC | ||||
| Hemoglobin | 0 | 0 | 3 | 0 |
| LABORATORY | ||||
| Magnesium, serum-low | 0 | 0 | 5 | 1 |
| Albumin, serum-low | 0 | 0 | 5 | 0 |
| Calcium, serum-low | 0 | 0 | 3 | 0 |
*
dose limiting toxicities