TABLE 2.

Patient immunological, serological and virological profiles.

Patient ID#	Gender	Age (years)	CD4 (cells/ mL)	Hbe Ag	HDV Ab	HBV DNA plasma log10 IU/mL	HBV DNA CSF log10 IU/mL	HIV RNA plasma log10 c/mL	HIV RNA CSF log10 c/mL	Albumin index (N < 9)	CSF albumin levels (g/L)	CSF pleocytosis (WBC/mL of CSF)	Previous cART	Length of current exposure to 3TC (months)	Neurological diagnosis	MRI demyelinating lesions
1	M	21	7	N/A	N/A	9.46	4.7	4.61	4.3	10.81	0.4	4	no	—	HIVE	yes
2	F	16	125	pos	N/A	8.84	3.36	6.01	2.48	N/A	N/A	N/A	yes	—	stroke	yes
3	M	18	37	N/A	N/A	8.72	4.69	2.79	2.6	18.86	0.66	46	yes	5	stroke	yes
4	M	17	490	pos	N/A	8.24	5.58	5.11	5.85	27.73	0.99	5	yes	—	HIVE	yes
5	M	17	220	N/A	N/A	7.65	5.36	4.18	3.44	17.55	0.66	N/A	no	—	viral encephalitis	no
6	F	15	8	N/A	N/A	7.54	3.42	4.58	2.72	2.62	0.1	3	no	—	viral encephalitis	yes
7	F	20	59	pos	neg	6.87	4.12	5.92	5.78	8.88	0.3	10	yes	2	CMV encephalitis	yes
8	M	14	13	pos	neg	6.34	3.3	5.34	4.36	12.35	0.4	5	No	—	Tx	—
9	M	17	1	pos	neg	5.77	4.91	5.61	2.89	73.33	1.98	20	yes	—	SME	yes
10	M	15	182	pos	neg	5.73	2.98	5.15	2.59	15.31	0.66	1	yes	—	facial paresis	normal
11	F	20	348	pos	N/A	5.73	1.78	4.11	3.32	6.01	0.2	3	no	—	HIVE	—
12	M	16	380	pos	N/A	5.07	1.78	2.25	2.25	2.06	0.1	3	yes	60	stroke	—
13	M	14	19	pos	neg	4.85	1.78	5.82	3.69	2.78	0.1	1	yes	49	PML	yes
14	F	20	231	neg	N/A	4.6	2.26	3.6	2.6	2.49	0.1	4	yes	13	SME	yes
15	M	15	7	pos	N/A	3.38	1.78	2.6	2.6	16.92	0.66	3	yes	1	PML	yes
16	M	16	306	pos	pos	3.24	1.78	2.6	2.6	2.65	0.1	2	yes	9	behaviour changes	no
17	M	17	16	neg	pos	3.15	1.78	4.8	2.6	2.53	0.1	1	yes	29	SME	yes
18	F	18	325	neg	neg	3.03	1.78	3.79	2.25	18.33	0.66	6	yes	36	epilepsy	normal
19	F	16	8	pos	pos	1.78	1.78	3.2	2.6	2.90	0.1	3	yes	45	evaluation Hodgkin lymphoma	normal
20	F	16	305	neg	N/A	1.78	1.78	3.62	4	33.08	1.32	22	yes	viral encephalitis	—
21	M	16	1	neg	pos	1.78	1.78	2.25	2.43	3.65	0.1	3	yes	42	SME	yes
22	F	18	220	neg	neg	1.78	1.78	1.7	1.7	2.54	0.1	12	yes	22	HIVE	no
23	M	18	738	N/A	N/A	1.78	1.78	1.7	1.7	2.45	0.1	2	yes	69	HIVE	—
24	F	20	406	neg	neg	1.78	1.78	1.67	1.67	2.34	0.1	2	yes	24	HIVE	—
25	F	19	255	neg	neg	1.78	1.78	2.72	1.7	2.38	0.1	4	yes	9	HIVE	—
26	M	21	146	neg	neg	1.78	1.78	4.8	5.1	6.90	0.2	22	no	—	HIVE	yes

Abbreviations: HBe Ag, hepatitis B e antigen; HDV Ab, hepatitis D virus antibodies; HBV, hepatitis B virus; CSF, cerebrospinal fluid; WBC, white blood cells; cART, combination antiretroviral therapy; HIVE, HIV encephalopathy; SME, measles inclusion body encephalitis or subacute myoclonic measles encephalitis; PML, progressive multifocal leucoencephalopathy; Tx, cerebral toxoplasmosis.