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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: Dev Biol. 2015 Feb 26;401(2):264–275. doi: 10.1016/j.ydbio.2015.02.014

Figure 2. Efficiency and distribution of Dermo1Cre-mediated mesenchymal recombination.

Figure 2

Whole mount images (A–D) and longitudinal sections (E, F) of Wlsf/f;Dermo1Cre/+;Rosa mT/mG embryos are shown. Dermo1Cre-mediated recombination is detected in the mesenchyme as early as E9.5 and progressively expands throughout the mesenchyme as development progresses (A–D). At E12.5, Dermo1Cre-mediated recombination in the body wall is extensive, as demonstrated by the GFP signal in both control and Wlsf/f;Dermo1Cre/+ embryos (E,F). Cre recombination, detected using GFP, was present in both aSMA (white arrows) and Sox9 (white arrowhead) stained cells of the ventral body wall (G,H and H’ insert).