Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 28;5:13. doi: 10.1186/s13395-015-0040-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© McCourt et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Dystrophin and utrophin constructs analyzed. (A) Diagram of full-length human dystrophin (hDys); NT - N-terminus, CR - cysteine-rich domain, CT - C-terminus, circles - spectrin-like repeats, diamonds - unstructured ‘hinge’ regions, ABD1/2 - actin binding domains, nNOS BD - neuronal nitric oxide synthase binding domain, MTBD - microtubule binding domain, DgBD - dystroglycan binding domain, Syn BD - syntrophin binding domain, DB BD - dystrobrevin binding domain. (B) Diagrams of exon-skipped human dystrophin constructs analyzed. (C) Diagrams of gene therapy human dystrophins analyzed. (D) Diagrams of full-length human utrophin (hUtr) and a micro-utrophin (μH2 hUtr) analyzed.