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. 2015 Apr 28;5:13. doi: 10.1186/s13395-015-0040-z

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© McCourt et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Analysis of protein aggregation by high-speed sedimentation. Quantification of high-speed sedimentation assay of supernatant (S) and pellet (P) fractions where % aggregation = S/(S + P); full-length human dystrophin (hDys) in black bar, exon-skipped dystrophins in gray bars, gene therapy dystrophins in white bars, and utrophins in lined bars; *P < 0.05, **P < 0.0001 using ANOVA statistical analysis compared to full-length human dystrophin. hUtr - human utrophin.