Table 3.

Univariate and multivariate hazard ratios (HR) of mortality following cART commencement for patients enrolled in the Australian HIV Observational Database between 1999 and 2013 with consent to data linkage (N=3,030)¹

		Univariate models			Multivariate model
		HR (95% CI)	p	P	HR (95% CI)	P	P
LTFU2,3	No	1		0.893	1		0.844
	Returned	0.95 (0.64–1.41)	0.803		1.12 (0.75–1.69)	0.570
	Yes	0.93 (0.69–1.26)	0.649		1.04 (0.77–1.43)	0.782
Gender	Male	1
	Female	0.93 (0.57–1.51)	0.759
Age4
	Per year	1.03 (1.02–1.04)	<0.001		1.04 (1.03–1.05)	<0.001
IDU5	No	1			1
	Yes	1.73 (1.21–2.48)	0.003		1.95 (1.34–2.84)	<0.001
Prior ADI4	No	I
	Yes	1.50 (1.14–1.97)	0.003
HCV (ever)	No	I
	Yes	1.45 (1.09–1.94)	0.012
HBsAg (ever)	No	1			1
	Yes	1.71 (1.14–2.55)	0.009		1.71 (1.14–2.57)	0.009
Year HIV Positive	<1996	1			1
	≥1996	0.57 (0.43–0.76)	<0.001		0.67 (0.50–0.91)	0.009
Year of first cART	<2000	1			1
	≥2000	0.64 (0.46–0.90)	0.009		0.66 (0.45–0.96)	0.028
CD4 cell count4	0–199	1		<0.001	1		<0.001
	200–349	0.59 (0.44–0.79)	<0.001		0.57 (0.42–0.77)	<0.001
	≥350	0.50 (0.38–0.67)	<0.001		0.49 (0.36–0.66)	<0.001
Prior Mono/Dual4	No	1
	Yes	1.43 (1.13–1.79)	0.002

¹Cox proportional hazards ratios. Baseline= cART commencement. Patients left truncated at enrolment. Multivariate model selection using forward stepwise selection with forced inclusion of LTFU status.

²LTFU if no recorded AHOD date other than AHOD death or NDI death within 1 year of cohort/site censor date or date of death. Lost to follow-up status time updated from 180 days after date of last AHOD visit date other than death. 1 subset of patients censored at 31 March 2007. 1 site censored at 31 March 2010. Administrative censored at 17 years of cART. Analyses stratified by treatment centre.

³Time updated variable

⁴At cART initiation

⁵Mode of exposure via intravenous drug use