Table 1.
Experimental groups of rats, injected activities and injected masses (mean ± SD)
| Control groups | HSE groups | Injected activity (MBq) | Injected mass (nmol) | ||
|---|---|---|---|---|---|
| PET SUV and ex vivo biodistribution | |||||
| [11C]CB184 | Scan 30 min | 4 | 4 | 17.2 ± 14.6 | 2.35 ± 0.81 |
| Scan 60 min | 3 | 3 | 48.9 ± 8.2 | 1.12 ± 0.29 | |
| Scan 30 min + pretreated with PK11195 | 3 | 3 | 11.3 ± 7.6 | 3.08 ± 1.09 | |
| Scan 60 min + pretreated with PK11195 | 2 | 2 | 41.2 ± 3.8 | 1.77 ± 0.73 | |
| Pharmacokinetic analysisp | |||||
| [11C]CB184 | Scan 60 min + blood sampling | 5 | 6 | 68.7 ± 22.7 | 2.74 ± 1.44 |
| (R)-[11C]PK11195 | Scan 60 min + blood sampling | 5 | 5 | 85.3 ± 20.8 | 2.27 ± 0.89 |