Table 2.

Ex vivo biodistribution of [¹¹C]CB184, expressed as SUV (mean ± SD) approximately 75 min after injection in control (PBS-treated) rats, HSE rats (infected with HSV-1), and rats pretreated with 5 mg/kg of PK11195 5 min before [¹¹C]CB184 injection

	Control group (n = 7)	HSE group (n = 7)	PBS + PK11195 group (n = 5)	HSE + PK11195 group (n = 5)
Brain
Amygdala/piriform cortex	0.30 ± 0.08	0.52 ± 0.21*	0.10 ± 0.05***	0.08 ± 0.06**
Olfactory bulb	1.06 ± 0.15	1.52 ± 0.22***	0.20 ± 0.08***	0.17 ± 0.11***
Cerebellum	0.52 ± 0.06	0.84 ± 0.41	0.13 ± 0.08***	0.11 ± 0.06**
Cingulate/frontopolar cortex	0.36 ± 0.13	0.46 ± 0.21	0.24 ± 0.17	0.10 ± 0.05**
Entorhinal cortex	0.36 ± 0.13	0.57 ± 0.39	0.09 ± 0.07**	0.10 ± 0.05*
Frontal cortex	0.44 ± 0.44	0.39 ± 0.09	0.10 ± 0.07	0.08 ± 0.05***
Hippocampus	0.39 ± 0.18	0.55 ± 0.21	0.12 ± 0.08*	0.09 ± 0.05***
Medulla	0.59 ± 0.14	1.51 ± 0.57**	0.12 ± 0.07***	0.13 ± 0.06***
Parietal/temporal/occipital cortex	0.32 ± 0.06	0.41 ± 0.14	0.10 ± 0.06***	0.10 ± 0.05***
Pons	0.63 ± 0.08	1.26 ± 0.52**	0.12 ± 0.08***	0.12 ± 0.10***
Striatum	0.28 ± 0.07	0.45 ± 0.15*	0.11 ± 0.07**	0.09 ± 0.06***
Whole brain	0.66 ± 0.16	0.99 ± 0.21**	0.15 ± 0.08***	0.08 ± 0.08***
Peripheral organs
Adrenals	14.84 ± 5.45	13.86 ± 4.42	7.72 ± 5.20*	8.14 ± 7.09
Bone	1.00 ± 0.26	0.98 ± 0.14	0.31 ± 0.19***	0.39 ± 0.24***
Colon	3.38 ± 0.97	3.29 ± 0.81	0.42 ± 0.24***	0.49 ± 0.36***
Fat	0.43 ± 0.21	0.57 ± 0.39	0.48 ± 0.18	0.72 ± 0.49
Heart	22.81 ± 2.80	23.69 ± 2.71	0.68 ± 0.40***	0.77 ± 0.53***
Ileum	6.41 ± 3.07	6.20 ± 2.67	2.31 ± 1.15*	2.74 ± 1.77*
Kidney	12.52 ± 2.22	13.17 ± 2.25	0.72 ± 0.44***	1.12 ± 0.75***
Liver	7.57 ± 1.64	7.97 ± 1.73	11.28 ± 5.43	10.71 ± 9.25
Lung	18.39 ± 2.20	22.53 ± 2.41**	0.95 ± 0.57***	1.62 ± 0.98***
Pancreas	3.55 ± 0.52	4.23 ± 0.76	0.57 ± 0.34***	0.62 ± 0.37***
Plasma	0.18 ± 0.08	0.28 ± 0.24	0.27 ± 0.15	0.19 ± 0.04
Red blood cells	0.19 ± 0.18	0.13 ± 0.01	0.11 ± 0.05	0.11 ± 0.07
Spleen	13.23 ± 2.64	11.76 ± 1.42	0.70 ± 0.47***	0.71 ± 0.55***
Stomach	5.04 ± 0.82	5.88 ± 1.87	0.70 ± 0.46***	0.82 ± 0.60***
Submandibularis	4.28 ± 1.02	4.89 ± 0.75	0.70 ± 0.46***	0.79 ± 0.56***
Testis	0.98 ± 0.11	0.88 ± 0.12	0.30 ± 0.24***	0.29 ± 0.21***
Thymus	3.36 ± 0.58	3.23 ± 0.33	0.72 ± 0.44***	0.74 ± 0.46***
Trachea	5.56 ± 1.50	6.38 ± 3.30	0.81 ± 0.35***	1.02 ± 0.70**

*p < 0.05, **p < 0.01, ***p < 0.001, HSE vs. control groups, and groups pretreated with PK11195 vs. the same group without pretreatment