Table 3.

[¹¹C]CB184 uptake, expressed as SUV (mean ± SD), obtained from the PET scan acquired for 50 – 60 min after [¹¹C]CB184 injection in control (PBS-treated) rats, HSE rats (infected with HSV-1), and rats pretreated with 5 mg/kg of PK11195 5 min before [¹¹C]CB184 injection

	Control group (n = 7)	HSE group (n = 7)	PBS + PK11195 group (n = 5)	HSE + PK11195 group (n = 5)
Amygdala	0.43 ± 0.11	0.49 ± 0.14	0.16 ± 0.02***	0.16 ± 0.05***
Olfactory bulb	0.84 ± 0.13	0.96 ± 0.18	0.21 ± 0.03***	0.26 ± 0.03***
Cerebellum	0.48 ± 0.08	0.62 ± 0.17	0.14 ± 0.02***	0.14 ± 0.03***
Frontal cortex	0.44 ± 0.12	0.42 ± 0.13	0.14 ± 0.02***	0.18 ± 0.03**
Remaining cortices	0.40 ± 0.07	0.45 ± 0.06	0.14 ± 0.01***	0.15 ± 0.02***
Hippocampus	0.31 ± 0.09	0.40 ± 0.11	0.13 ± 0.03**	0.12 ± 0.03***
Hypothalamus	0.47 ± 0.15	0.56 ± 0.10	0.16 ± 0.03***	0.18 ± 0.05***
Medulla	0.47 ± 0.08	0.86 ± 0.27**	0.19 ± 0.04***	0.19 ± 0.06***
Midbrain	0.33 ± 0.09	0.42 ± 0.12	0.11 ± 0.02***	0.13 ± 0.03***
Pons	0.44 ± 0.11	0.73 ± 0.17**	0.18 ± 0.03***	0.19 ± 0.05***
Septum	0.29 ± 0.12	0.40 ± 0.16	0.10 ± 0.01**	0.12 ± 0.03**
Striatum	0.29 ± 0.09	0.38 ± 0.06*	0.11 ± 0.03**	0.17 ± 0.05***
Thalamus	0.26 ± 0.07	0.33 ± 0.07	0.12 ± 0.02**	0.11 ± 0.03***
Whole brain	0.41 ± 0.08	0.52 ± 0.08*	0.14 ± 0.01***	0.15 ± 0.02***

*p < 0.05, **p < 0.01, ***p < 0.001, HSE vs. control groups, and groups pretreated with PK11195 vs. the same group without pretreatment