Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 30;290(19):12210–12221. doi: 10.1074/jbc.M115.646893

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 6. — Voltage-gated Ca²⁺ currents are decreased in EHD3 cKO atrial myocytes. A, current-voltage relationship of the I_Ca,T in WT and EHD3 cKO atrial myocytes. I_Ca,T is significantly different across all relevant physiologically voltages (n = 11 WT, n = 14 atria). B, peak I_Ca,T is significantly decreased in EHD3 cKO myocytes (−0.558 versus −0.292 pA/pF, WT versus EHD3 cKO p < 0.05). C, current-voltage relationship of the I_Ca,L in WT and EHD3 cKO atrial myocytes. I_Ca,L is significantly different across all relevant physiologically voltages (n = 11 WT, n = 14 EHD3 cKO atria). D, peak I_Ca,L is significantly decreased in EHD3 cKO myocytes (−1.71 versus −1.09 pA/pF, WT versus EHD3 cKO, p < 0.01). E and F, I_Na and I_Na inactivation are both unchanged by loss of EHD3 in atrial myocytes. G, representative patch clamp protocol applied to an atrial myocyte to assess I_Ca,T and I_Ca,L at a test potential of −20 mV. H, representative raw current traces of both T-type and L-type current in WT and EHD3 cKO atrial myocytes.