FIGURE 1.

The central domain of Exo1 limits its association with DNA damage. A, left panel, wild-type Exo1 and the truncation mutants used in this study. Right panel, representative images showing the association of GFP-tagged Exo1 and deletion mutants with microirradiation-induced damage. Red lines indicate the sites of laser irradiation in cells. B, the time course for damage association by GFP-Exo1 and truncation mutants is shown during the first 20 min after laser irradiation. Each data point is the average of independent measurements from five cells. Error bars represent mean ± S.D.