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The interaction of Exo1 with PCNA is suppressed by binding of 14-3-3 proteins to the central region of Exo1. A, coimmunoprecipitation (IP) of PCNA and 14-3-3s with FLAG-Exo1(WT) or FLAG-Exo1(ΔCR) shows that deletion of the central region enhances binding to PCNA while interfering with binding to 14-3-3s. B, coimmunoprecipitation of PCNA and 14-3-3s with FLAG-Exo1(WT) or FLAG-Exo1(ΔCR) in 293T cells overexpressing mCherry, mCherry-Difopein(WT), or mCherry-Difopein(MUT).
