TABLE 4.
Effect of lactadherin-derived peptides on cell viability and Wa rotavirus infectivity in MA104 cells
| Peptides | Features | IC50 | 95% confidence Interval | CC50 | SI |
|---|---|---|---|---|---|
| μm | μm | ||||
| pDGE | peptide DGE, 8 aa, equine | 17.3 | 6.9–43.5 | >880 | >50.9 |
| pAGE | aa substitution in position 3 | 256.6 | 177.7–370.3 | >880 | >3.4 |
| pDGE-RGD | Wild type peptide | 4.4 | 2.7–7.1 | >880 | >200 |
| pAGE-RGD | aa substitution in position 3 | >220 | NAa | >880 | >4 |
| pDGE-RGE | aa substitution in position 16 | >220 | NA | >880 | >4 |
| pAGE-RGE | aa substitutions in position 3 and 16 | >220 | NA | >880 | >4 |
| pDGE-RGDmut1 | aa substitution in position 1 | 13.5 | 5.1–35.7 | >880 | >65.2 |
| pDGE-RGDmut2 | aa substitution in position 13 | 13.1 | 7.5–22.9 | >880 | >67.2 |
| pDGE-RGDmut3 | aa substitution in position 19 | 6.7 | 2.2–20.4 | >880 | >131.3 |
a n.a., not assessable.