Fig. 4.

An iceLogo of the amino acid context of the oxidized methionine. The sequence context of proteins with significantly (p ≤ 0.05) increased oxidation over time (n = 17) reveals a preference (p ≤ 0.01) for hydrophobic amino acids surrounding the site of methionine oxidation. As a negative reference set, the remaining 158 proteins with identical MetO peptides identified in both time points were chosen. Methionine was fixed at P6 and the five surrounding amino acids; both N-terminal (P1–P5) and C-terminal amino acids (P7–P11) are shown.