Table 2.
Group | A (unopposed estrogen, n = 30) | B (estrogen-progestin combination, n = 31) | C (placebo, n = 24) | ||||||
baseline | after* | Δ | baseline | after* | Δ | baseline | after* | Δ | |
Homocysteine (µmol/l) | 8.8±3.5 | 6.9±2.5a | - 21.6±- 29.8b | 9.6±3.4 | 8.4±3.1a | - 12.2±- 28.9c | 9.7±3.4 | 11.3±5.3 | 16.5±55.1 |
C-reactive protein (mg/l) | 3.0±2.0 | 6.0±5.5a | 100.5±127.1 b | 3.1±2.2 | 5.9±4.3 a | 93.5±96.4c | 3.2±1.4 | 4.0±2.1 a | 25.5±48.9 |
*After six months of treatment; Δ = [(value after treatment - baseline value)/baseline value * 100]. The statistical analyses showed no difference between the groups' baseline homocysteine and C-reactive protein levels; a – p<0.01 compared with baseline (Wilcox test); b – p<0.01 compared with Δ of the other groups (Kruskal-Wallis and Dunn tests); c – p<0.01 compared with Δ of Group C (Kruskal-Wallis and Dunn tests).