Fig. 1.
NGF, BDNF, and synapsin I protein levels in hippocampal dentate gyrus following treadmill exercise after social isolation. (A) NGF, (B) BDNF, and (C) synapsin I. NGF, BDNF, and synapsin I protein level were significantly decreased in the ICG as compared to the GCG, and these levels were significantly improved in the IEG. GCG: group housing and control group, n = 10; GEG: group housing and exercise group, n = 10; ICG: isolated housing and control group, n = 10; IEG: isolated housing and exercise group, n = 10 (respectively 5 rats for immunohistochemistry, 5 rats for western blotting). Significant difference among groups at p < 0.001. Different letters represent significant variations calculated by 1-way analysis of variance (ANOVA) and the LSD test.