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. 2015 Apr 24;16:43. doi: 10.1186/s12863-015-0201-4

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© Andreeva et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Unique and common loop-motifs and individual molecular loop-components related to early (24 h) and late (7d) stages post-IR injury. At 0 h, there were no significant closed loop-motives. A. Closed loop-motifs. B. Transcripts (mRNAs) representing target genes. C. microRNAs (miRs). D. transcription factors (TFs). There were a higher number of loop motifs at 24 h than at 7d. Moreover, there were more representations of mRNAs, miRs and TFs at 24 h compared with the 7d, whether they were unique or common. The pattern of node relationships for the molecular components is typical in that the numbers of TF < miRs < mRNAs.