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. 2015 Apr 24;16:43. doi: 10.1186/s12863-015-0201-4

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© Andreeva et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Highly interconnected networks of loop motifs related to early (24 h) and late (7d) post-IR injury periods. A. Regulatory network at 24 h consisting of 2681 closed loop-motifs, with only 45 in common with the 7d time point. B. Regulatory network at 7d consisting of 699 closed loop-motifs, with only 45 in common with the 24 h time point. Each motif is composed by a microRNA (miR, filled green circle) a transcription factor (TF, filled red circle) and a related protein-coding gene transcript (filled blue circle). Every node (miRNA, TF and TG) represents a differentially expressed molecular element with altered expression in retinal ischemia-reperfusion injury, when compared to sham control animals.