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. 2015 Apr 24;16:43. doi: 10.1186/s12863-015-0201-4

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© Andreeva et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Sub-networks at 7d associated with 5 particular cellular processes all being a part of the larger regulatory network seen in Figure 3B. A. Loop-motifs related to cell death. B. Loop-motifs related to antigen presentation. C. Loop-motifs associated with ion transport. D. Loop-motifs associated with immune responses. E. Loop-motifs associated with inflammatory responses. The thicker edges highlight the loop motifs that involve rno-miR-185. This miR has been associated with inflammatory responses during brain ischemic stroke in mice and is potential target for prevention and treatment of stroke (ref. [65]). Green filled circles denote miRs, red filled circles denote TFs and blue filled circles denote target genes/transcripts.