Table 4.
Top ten transcription factors, mRNAs and miRs ranked by the number of their connections at the 2 time points 24 h and 7d post-IR injury
| miR (24 h) | C | miR (7d) | C | mRNA (24 h) | C | mRNA (7d) | C | TF (24 h) | C | TF (7d) | C |
|---|---|---|---|---|---|---|---|---|---|---|---|
| miR-495* | 172 | miR-873 | 55 | Dhcr24 | 22 | Igf1 | 21 | Maf | 389 | Lef1 | 124 |
| miR-214 | 170 | miR-223 | 48 | Map2 | 22 | Prrx1 | 16 | Stat1 | 165 | Stat1 | 106 |
| miR-207 | 143 | miR-410 | 45 | Hmox1 | 21 | Xpr1 | 16 | Creb1 | 104 | Bcl6 | 98 |
| miR-298 | 132 | miR-185 | 45 | Pcdha4 | 21 | Dhcr24 | 14 | Nptx1 | 29 | Stat3 | 12 |
| miR-466b | 111 | miR-291a-3p | 44 | Foxp1 | 21 | Slc26a4 | 14 | Tp53 | 28 | Runx1 | 8 |
| miR-206 | 104 | miR-495 | 43 | Samd12 | 20 | Glce | 13 | Foxp1 | 21 | Cebpb | 8 |
| miR-19a | 102 | miR-329 | 40 | Kcnc1 | 19 | Slc18a2 | 13 | Isl1 | 18 | Litaf | 7 |
| miR-221 | 95 | miR-207 | 35 | Ppp1r9a | 19 | Stat3 | 12 | Nr2c2 | 15 | Arida5a | 6 |
| miR-297 | 91 | miR-138 | 31 | Rictor | 19 | Fut4 | 12 | Gnb1 | 12 | Lgals3 | 4 |
| miR-33 | 90 | miR-539 | 28 | Dclk1 | 19 | Scarb2 | 12 | Rnf138 | 7 | Arpc1b | 3 |
*Bold denotes the common molecular components between the early and late post-IR time points.
We have rank-ordered each of the 3 molecular components by their relative connectivity and used this as a marker of relative importance within networks at the 2 time points. Note that there are a few molecular components which are common to both time points. For example rno-miR-495 and rno-miR-207 are common between the 24 h and 7d time points, but they are rank-ordered differently between the 2 time points. In addition, Stat1 is present and equally rank-ordered at both time points. C = number of connections.