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. 2015 Apr 17;8:14. doi: 10.1186/s13072-015-0007-7

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© Sanchez-Vega et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Associations between CIMP status and clinical annotations. (A) Age vs. CIMP status across 12 cancer types. (B) Overall survival curves for the four cancer types exhibiting significant differences based on CIMP status (BRCA, KIRC, LUSC, UCEC) and overall survival curves for luminal A and luminal B subtypes in BRCA based on CIMP status. (C) Microsatellite instability vs. CIMP status in COAD, READ, and UCEC. (D) CIMP status as a function of anatomic subdivision in COAD. P-values come from a Kruskal-Wallis test for difference in medians in panel (A), a log-rank test for survival curve differences in panel (B), and Fisher’s exact test in panels (C) and (D). For each survival curve in (B), the number of CIMP−/CIMP+ samples is provided next to the corresponding P-value.