Table 2.

Univariate analysis of potential risk factors for CVC malfunction

Variable	Hazard ratio (95% CI)	P-value
Treatment group		0.02
Heparin-only	1.91 (1.13, 3.22)
rt-PA	Ref.
Age	1.01 (0.99, 1.03)	0.275
Duration of dialysis	0.59 (0.26, 1.38)	0.224
Number of catheters in prior year	1.20 (0.92, 1.57)	0.172
Hemoglobin	1.00 (0.98, 1.02)	0.950
Albumin	1.00 (0.96, 1.04)	0.927
Platelets	1.00 (1.00, 1.00)	0.509
Gender		0.073
Male	Ref.
Female	1.57 (0.95, 2.59)
First dialysis catheter ever		0.878
No	Ref.
Yes	1.04 (0.62, 1.74)
Diabetes		0.352
No	Ref.
Yes	1.27 (0.76, 2.12)
History of rt-PA use for catheter malfunction		0.082
No	Ref.
Yes	1.89 (1.04, 3.46)
CVC reversed at the session prior to the event or censoring:		<0.001
No	Ref.
Yes	11.2 (6.35, 19.7)
> = 1 CVC reversed in the 6 sessions prior to the event or censoring:		<0.001
No	Ref.
Yes	9.50 (4.52, 20.0)
Number of HD sessions with CVC reversed in the 6 sessions prior to the event or censoring	1.71 (1.51, 1.93)	<0.0001
Mean blood processed in the prior 6 runs (L)  < 65	5.26 (2.00 – 13.87)	<0.001
65 - 74	3.23 (1.22 – 8.58)
75 - 84	1.50 (0.51 – 4.41)
85+	Reference
Mean blood flow in the prior 6 runs (mL/min)		<0.001
< 300	8.45 (3.20 –22.34)
300 - 324	6.80 (2.49 – 18.56)
325 - 349	2.77 (0.90 – 8.49)
350+	Reference