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. 2015 Apr 3;13:29. doi: 10.1186/s12951-015-0088-2

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© Maiolino et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Structure and properties of NPs during layering procedure. A) Schematic representation of the double coating process. B) Size, polydispersity (PI) and zeta potential of NPs during coating and after dispersion of NPs freeze-dried with trehalose in water. Results are the mean of three measurements obtained on three different NP batches ± SD. C) TEM micrographs of PLGA/PEI/HA NPs.