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. 2015 Apr 3;13:29. doi: 10.1186/s12951-015-0088-2

Table 1.

Properties of DTX-loaded NPs before and after freeze-drying

DTX-PLGA/PEI NPs DTX-PLGA/PEI/HA NPs DTX-PLGA/PEI NPs freeze-dried DTX-PLGA/PEI/HA NPs freeze-dried
Trehalose/NP weight ratio - 60
Yield (% ± SD) 21.2 ± 0.8a -
Mean DH (nm ± SD) 155 ± 9b 173 ± 10b 176 ± 4c 203 ± 10c
Polydispersity index 0.10b 0.13b 0.20c 0.17c
Zeta Potential (mV) +39.0b −23.2b +33.5c −22.3c
DTX actual loading(mg per 100 mg) 0.95 ± 0.5 0.013 ± 0.001
PEI actual loading(mg per 100 mg) 7.94 ± 2.1 0.132 ± 0.010
HA actual loading(mg per 100 mg) - 12.2 ± 0.8 - 0.20 ± 0.03

aCalculated as ratio between total component weight and NP weight.

bAs prepared NPs before freeze-drying.

cAfter dispersion of freeze-dried powder in water.