Table 2.
Chol flip–flop rates for two simulated systems (columns) without and with chlf (rows). Flip–flop distribution with respect to the phasic nature of donor and acceptor lipid phasesa,b.
| DUPC/DPPC/Chol |
DUPC/DSPC/Chol |
|||
|---|---|---|---|---|
| no chlf | 1.41 μs−1 | 87.7% ld–ld 12.3% lo–ld 0% lo–lo |
0.97 μs−1 | 67% ld–ld 33% lo–ld 0% lo–lo |
| 0.77 chlf per lipid | 2.25 μs−1 | 90.5% ld–ld 9.1% lo–ld 0.4% lo–lo |
2.01 μs−1 | 78.8% ld–ld 18.5% lo–ld 2.7% lo–lo |
aFlip–flop rates were computed by tracking the orientation of chol molecules every 200 ps during 1 μs of simulation.
bThe phasic nature of the donor and acceptor lipid phases was assigned following the same criteria to compute the segregation and interleaflet coupling parameters Φ and Λ.