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LA and AA metabolites play roles in both inflammation and resolution. Solid lines indicate proinflammatory pathways, and dotted/dashed lines represent anti-inflammatory/proresolving pathways. AA, arachidonic acid; CYP450, cytochrome P450; EET, epoxyeicosatrienoic acids; HETE, hydroxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid; LA, linoleic acid; LO, lipoxygenase; LTB4, leukotriene B4; LTX, leukotoxin; NO, nitrosylated; PGE2, prostaglandin E2.
