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. 2015 May 8;9:167. doi: 10.3389/fncel.2015.00167

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Copyright © 2015 Braidy, Poljak, Grant, Jayasena, Mansour, Chan-Ling, Smythe, Sachdev and Guillemin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered SIRT1 activity in the aging rat brain. Reduced SIRT1 activity was observed in the aging rat brain after 12 months of age using a fluorimetry based assay which detected the deacetylation of lysine residues. All values are means ± S.E.M. using brains from eight rats for each age group. Significance ^*p < 0.01 compared to 3 month old rats.