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. 2015 May 8;9:167. doi: 10.3389/fncel.2015.00167

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Copyright © 2015 Braidy, Poljak, Grant, Jayasena, Mansour, Chan-Ling, Smythe, Sachdev and Guillemin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced SIRT1 activity promotes p53 acetylation in the aging brain. Acetylated p53 and total p53 levels were determined by Western blotting in (A) frontal lobe, (B) temporal lobe, (C) occipital lobe, and (D) hippocampus in the brain with aging using anti-acetylated p53 and anti-total p53 antibodies. The blots shown are representative tracings of an experiment repeated eight times. Graphs are mean ± S.E brains of data from brains using eight rats for each age group. Significance ^*p < 0.01 was established by comparison with 3 month old rats.