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. 2015 May 8;6:123. doi: 10.3389/fphys.2015.00123

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Copyright © 2015 Leite, Almeida, Lopes and Dias da Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment using cardiac stem cells and associated outcomes. Results support the feasibility and safety of the cardiac stem cell delivery procedures, although the reports of outcomes have been limited and primarily concerned to functional improvements or reductions in the infarct size. Future studies will allow investigate other equally important outcomes, such as improvements in the quality of life, maintaining the improvement in ventricular function over time, and decreasing the mortality rate, among others. However, there is still much to be explored in basic studies, which may reveal the reasons why therapy using cardiac stem cells is not able to heal the injured heart.