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. 2014 Dec 24;24(10):1194–1204. doi: 10.1089/scd.2014.0437

FIG. 6.

FIG. 6.

Transcriptional changes to Wnt signaling and osteo-related genes during osteoinduction. (A) Differences in Osterix (OSX) mRNA levels among the groups during osteogenesis. The changing trend was similar among groups, and the highest OSX mRNA expression occurred on the seventh day of osteogenesis. (B) There were no significant differences in alkaline phosphatase (ALP) mRNA expression among the groups, but it did gradually increase during osteogenesis. (C) The bone sialoprotein (BSP) transcription levels among the groups. The BSP mRNA expression levels were much lower in the Rev-erbα group and the low level was maintained, while BSP mRNA expression in the other two groups increased markedly during osteogenesis. (D) The β-catenin mRNA expression among groups showed the same trend as that observed for BSP. (E) Differences in c-Myc mRNA levels among the groups. No expression differences could be found among the groups, and the expression gradually increased during osteogenesis. Data represent the mean±SD (n=3), and the * symbol denotes a significant difference (P<0.05).