Cardiac output and blood pressure over time for the four conditions (mean ± SEM). Left, cardiac output (L/min) was higher in the LPS group and LPS plus EUK-134 groups than the control group (p < 0.02 and p < 0.005, respectively). Cardiac output in EUK-134 alone was also higher than control (p < 0.001) and LPS alone (p < 0.005); Right, blood pressure (BP) was lowest in the LPS group but was not significantly different from control (p < 0.068); This drop was rescued in the LPS plus EUK-134 group, which was superimposable with the control group. BP was best maintained or slightly rose in the EUK-134 group; This group was significantly greater than the LPS (p < 0.001), control (p < 0.001), and LPS plus EUK-134 group (p < 0.001). *
p < 0.02, 0.005 or 0.001.