Table 3.
Differentially expressed genes between myostatin propeptide transgenic and littermate control mice. (FPKM ≥ 5; fold change ≥ 2). inf represent the fold change cannot be calculated because the expression level was not detectable in wild-type mice.
| Gene ID | Gene | Official Full Name | CN Value | TN Value | Fold Change | p-Value |
|---|---|---|---|---|---|---|
| Genes Related to Cytoskeleton and Muscle Development | ||||||
| XLOC_010673 | Myh6 | Myosin heavy polypeptide 6 | 5.49 | 0.70 | −7.83 | 0.00010 |
| XLOC_000666 | Mybph | Myosin binding protein H | 14.77 | 57.60 | 3.90 | 0.00005 |
| XLOC_003363 | Rmst | Rhabdomyosarcoma 2 associated transcript | 0.53 | 15.11 | 28.72 | 0.00005 |
| XLOC_006460 | Actg1 | Actin gamma cytoplasmic 1 | 11.26 | 355.42 | 31.56 | 0.00005 |
| XLOC_019664 | Actc1 | Actin alpha cardiac muscle 1 | 50.30 | 257.64 | 5.12 | 0.00005 |
| XLOC_034484 | Ky | Kyphoscoliosis peptidase (CD1) | 3.26 | 8.81 | 2.70 | 0.00015 |
| XLOC_026810 | Actb | Actin beta | 26.24 | 67.11 | 2.56 | 0.00020 |
| XLOC_000205 | Mstn-pro | Myostatin propeptide | 32.03 | 409.35 | 12.78 | 0.00005 |
| Genes Related to Lipoprotein Metabolic Process and Intracellular Signaling Cascade | ||||||
| XLOC_034105 | Apoa1 | Apolipoprotein A-I | 11.04 | 1.76 | −6.27 | 0.00025 |
| XLOC_019500 | Dgkz | Diacylglycerol kinase zeta | 22.14 | 90.10 | 4.07 | 0.00025 |
| XLOC_000353 | Plcd4 | Phospholipase C delta 4 | 3.76 | 17.38 | 4.63 | 0.00010 |
| XLOC_025320 | Alb | Albumin | 83.44 | 9.80 | −8.51 | 0.00005 |
| XLOC_002012 | G0s2 | G0/G1 switch gene 2 | 4.35 | 23.62 | 5.42 | 0.00005 |
| Genes for Immune Response | ||||||
| XLOC_007714 | Ighm | Immunoglobulin heavy constant mu | 27.24 | 73.44 | 2.70 | 0.00020 |
| XLOC_007114 | Tnfaip2 | Tumor necrosis factor alpha-induced protein 2 | 3.90 | 17.93 | 4.60 | 0.00010 |
| XLOC_031749 | Trim12c | Tripartite motif-containing 12C | 0.34 | 34.88 | 103.84 | 0.00025 |
| Genes for Oxidation Reduction | ||||||
| XLOC_006482 | Cbr2 | Carbonyl reductase 2 | 4.44 | 41.62 | 9.37 | 0.00010 |
| XLOC_010336 | Mss51 | Mitochondrial translational activator | 77.38 | 16.04 | −4.83 | 0.00005 |
| XLOC_020605 | Kcnab1 | Potassium voltage-gated channel shaker-related Subfamily beta member 1 | 2.86 | 11.06 | 3.87 | 0.00020 |
| Genes for Cell Proliferation | ||||||
| XLOC_001651 | Ptprc | Protein tyrosine phosphatase receptor type C (CD45) | 0.81 | 7.90 | 9.77 | 0.00005 |
| XLOC_026557 | Gm13841 | Predicted gene 13841 (ribosomal protein L29) | 0.00 | 8.32 | inf | 0.00005 |
| Genes of Proteolysis | ||||||
| XLOC_024383 | Zmpste24 | Zinc metallopeptidase STE24 | 5.67 | 27.67 | 4.88 | 0.00015 |
| Genes of Carbohydrate Phosphatase Activity | ||||||
| XLOC_018711 | Pfkfb3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 8.83 | 30.52 | 3.46 | 0.00005 |
| Genes of Integral to Membrane, Intrinsic to Membrane | ||||||
| XLOC_015439 | Aqp4 | Aquaporin 4 | 2.40 | 6.81 | 2.83 | 0.00020 |
| Genes of Extracellular Region | ||||||
| XLOC_025292 | Csn1s2a | casein alpha s2-like A | 0.00 | 8.54 | inf | 0.00005 |
| Others | ||||||
| XLOC_029580 | Josd2 | Josephin domain containing 2 | 109.35 | 22.64 | −4.83 | 0.00005 |
| XLOC_025924 | Gm15459 | Predicted gene 15459 (heat shock protein 8 pseudogene) | 7.46 | 21.77 | 2.92 | 0.00005 |
| XLOC_003234 | Odf3l2 | Outer dense fiber of sperm tails 3-like 2 | 14.39 | 57.11 | 3.97 | 0.00005 |