Table 2.
Antibacterial activity of water-soluble β-chitosan and antibiotics against drug-resistant bacteria. Antibacterial assay was performed in pH 7.4.
| Bacteria | MIC (μg/mL) | ||||||
|---|---|---|---|---|---|---|---|
| β5k | β10k | PIP a | AMP a | CIP a | GM a | TET a | |
| Gram(−) bacteria | |||||||
| P. aeruginosa ATCC 27853 | 9 | 9 | <4 | <2 | 0.25 | 0.5 | – |
| P. aeruginosa BMP-Pa001 | <4.5 | <4.5 | >128 | >32 | 2 | 1 | – |
| P. aeruginosa BMP-Pa002 | <4.5 | <4.5 | 16 | >32 | >8 | 8 | – |
| P. aeruginosa BMP-Pa003 | <4.5 | <4.5 | >128 | >32 | >8 | 32 | – |
| P. aeruginosa BMP-Pa004 | <4.5 | <4.5 | 16 | >32 | 0.25 | 1 | – |
| P. aeruginosa BMP-Pa005 | <4.5 | <4.5 | >128 | >32 | 0.25 | 8 | – |
| Gram(+) bacteria | |||||||
| S. aureus ATCC 25923 | 18 | 9 | – | – | 0.25 | 0.25 | 0.5 |
| S. aureus BMP-Sa001 | <4.5 | <4.5 | – | – | 1 | 0.25 | >16 |
| S. aureus BMP-Sa002 | 39 | 18 | – | – | >8 | >16 | 1 |
| S. aureus BMP-Sa003 | 39 | 18 | – | – | >8 | >16 | >16 |
| S. aureus BMP-Sa004 | 18 | 9 | – | – | >8 | >16 | >16 |
| S. aureus BMP-Sa005 | 39 | 18 | – | – | >8 | >16 | >16 |
P. aeruginosa BMP-Pa and S. aureus BMP-Pa strains are resistant-strains isolated from patients in the hospital. a PIP, AMS, CIP, GM, and TET are piperacillin, ampicillin, ciprofloxacin, gentamicin, and tetracycline, respectively.