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. 2015 Apr 13;16(4):8168–8185. doi: 10.3390/ijms16048168

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Electron microscopic images showing qualitative changes in ultrastructure of the left ventricle of rat hearts. (A) Electron micrograph of control rat heart showing normal architecture of cardiomyocytes and without changes in ECS; (B) Electron micrograph of the myocardium after treatment with QCT; (C) Electron micrograph of the myocardium affected with DOX demonstrating subcellular alterations of cardiomyocytes and extracellular space (arrows); (D) Ultrastructure of the myocardium of rats treated with both QCT and DOX. Arrows indicate improvement of some deleterious subcellular alterations induced by DOX. ECS: extracellular space; cmc: cardiomyocytes; cap: capillary; col: collagen; mit: mitochondria; vac: vacuole; fib: fibroblast. (A) original magnification ×8000; (B) original magnification ×8000; (C) original magnification ×6000; (D) original magnification ×6000.