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. 2015 Apr 13;16(4):8168–8185. doi: 10.3390/ijms16048168

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Effects of quercetin on ischemic tolerance of hearts isolated from normal and doxorubicin-treated rats. (A) Postischemic recovery of the left ventricular developed pressure LVDP; (B) Postischemic recovery of the maximal rate of pressure development +(dP/dt)_max; (C) Postischemic recovery of the maximal rates of pressure fall −(dP/dt)_max; (D) Postischemic recovery of the coronary flow. The recovery of parameters was determined after 30 min lasting global ischemia followed by a 40-min reperfusion. The recovery of parameters was expressed as a percentage of pre-ischemic baseline values. Each bar represents mean ± S.E.M. of eight independent measurements. ^a p < 0.05 vs. control saline-treated (−DOX) rats; ^b p < 0.05 vs. DOX-treated (+DOX) rats.