Table 1.
Effects of quercetin on biometric parameters in normal and doxorubicin-treated rats. BW, body weight; HW, heart weight; LV, left ventricle; SBP, systolic blood pressure; HR, heart rate; C, control rats; QCT, quercetin-treated rats; DOX, doxorubicin-treated rats; DOX–QCT, rats treated with both doxorubicin and quercetin. Data are presented as the mean ± SEM (n = 12 per group). Statistical significance was revealed by one way ANOVA with Bonferroni post-hoc test and statistical differences were always determined among groups C and DOX (or QCT) (a) as well as DOX and DOX–QCT (b), a p < 0.05 vs. C, b p < 0.05 vs. DOX. Statistically significant changes are in Table marked in bold.
| Parameter | C | QCT | DOX | DOX–QCT |
|---|---|---|---|---|
| BW (g) | 432.7 ± 13.3 | 428.6 ± 21.3 | 384.6 ± 16.8 a | 355.4 ± 17.1 |
| Weight gain (g) | 154.8 ± 11.9 | 153.5 ± 14.4 | 107.2 ± 13.2 a | 89.3 ± 16.3 |
| HW (g) | 1.43 ± 0.09 | 1.37 ± 0.12 | 1.26 ± 0.07 | 1.11 ± 0.06 |
| HW/BW | 3.325 ± 0.196 | 3.162 ± 0.211 | 3.282 ± 0.176 | 3.170 ± 0.174 |
| LV (mg) | 870.6 ± 51.3 | 841.7 ± 86.3 | 822.7 ± 39.5 | 740.8 ± 34.0 |
| SBP (mm·Hg) | 113 ± 4 | 120 ± 3 | 137 ± 4 a | 118 ± 5 b |
| HR (beats/min) | 369 ± 5 | 376 ± 16 | 392 ± 6 a | 368 ± 9 b |