Figure 6.

Stylized patterns of specific (solid areas, SeCys) and non-specific (hashed areas, presumed to be mostly SeMet in albumin) major components of plasma Se in subjects varying in Se status by consuming SeMet-containing foods. Not shown: Se occurring as SeMet in GPX3 and SEPP1, as their potential contributions to non-specific plasma Se are very small (<0.1%). Group labels: deficient = less than maximal selenprotein expression; adequate = maximal selenoprotein expression, i.e., meets nutritional requirement; “healthful” = supranutritional, including anti-tumorigenic doses; high = greater than needed for anti-tumorigenesis, but without adverse effects.