Table 3.
Associations between candidate CNV loci and the risk of obesity.
| Locus | Type | Obese Children (n, %) | Non-Obese Children (n, %) | OR (95%CI) 1 | p-Value 2 | p (FDR) 3 |
|---|---|---|---|---|---|---|
| 11q11 | normal | 218 (41.2) | 232 (46.6) | 1 | ||
| deletion | 123 (23.3) | 92 (18.5) | 1.43 (1.03–1.98) | 0.03 | 0.05 | |
| duplication | 188 (35.5) | 174 (34.9) | 1.15 (0.87–1.52) | 0.32 | 0.75 | |
| 5q13.2 | normal | 386 (73.0) | 369 (74.1) | 1 | ||
| deletion | 68 (12.9) | 59 (11.8) | 1.10 (0.76–1.61) | 0.61 | 0.61 | |
| duplication | 75 (14.2) | 70 (14.1) | 1.02 (0.72–1.46) | 0.90 | 0.90 | |
| 10q11.22 | normal | 459 (86.8) | 464 (93.2) | 1 | ||
| deletion | 52 (9.8) | 22 (4.4) | 2.40 (1.43–4.00) | 9.1 × 10−4 | 0.006 | |
| duplication | 18 (3.4) | 12 (2.4) | 1.51 (0.72–3.18) | 0.28 | 0.75 | |
| 10q11.22(2) | normal | 490 (92.6) | 472 (94.8) | 1 | ||
| deletion | 25 (4.7) | 15 (3.0) | 1.61 (0.84–3.10) | 0.15 | 0.21 | |
| duplication | 14 (2.6) | 11 (2.2) | 1.23 (0.55–2.73) | 0.62 | 0.87 | |
| 6q14.1 | normal | 270 (51.0) | 257 (51.6) | 1 | ||
| deletion | 202 (38.2) | 180 (36.1) | 1.07 (0.82–1.39) | 0.61 | 0.61 | |
| duplication | 56 (10.6) | 61 (12.2) | 0.87 (0.58–1.30) | 0.50 | 0.87 | |
| 4q25 | normal | 500 (94.5) | 487 (97.8) | 1 | ||
| deletion | 23 (4.3) | 6 (1.2) | 3.77 (1.52–9.36) | 0.004 | 0.01 | |
| duplication | 6 (1.1) | 5 (1.0) | 1.16 (0.35–3.83) | 0.81 | 0.90 |
1,2 Odds ratio, 95% confidence interval and p-values of deletions and duplications were calculated by logistic regression adjusted for gender and age, using normal CNV state as reference; 3 p (FDR) values represented the adjusted p-values for false discovery rate. CNV, copy number variation.