Table 2.
Characteristics of Included Studies: rTMS Variables
| Source | rTMS site |
rTMS frequency |
Intensity, % | No. of pulsesa | Treatment duration |
Sham-rTMS |
|---|---|---|---|---|---|---|
| Siebner et al,42 2000 | M1 | 5 Hz | 90 RMT | 2250 (2250 × 1) | 1 d | Tilted coil |
| Boylan et al,35 2001 | SMA | 10 Hz | Approximately 96 MT | 2000 (2000 × 1) | 1 d | Tilted coil |
| Shimamoto et al,28 2001 | Frontal | 0.2 Hz | 700 V | 480 (60 × 8) | 2 mo | Inactive coil and sound |
| Khedr et al,24 2003 | M1 | 5 Hz | 120 RMT | 20 000 (2000 × 10) | 10 d | Tilted coil |
| Lefaucheur et al,39 2004 | M1 | 0.5 and 10 Hz | 80 RMT | 600 (600 × 1); | 1 d | Sham coil |
| Khedr et al,33 2006 | M1 | 10 Hz | 100 MT | 2000 (2000 × 1) | 6 d | Occipital stimulation |
| Lomarev et al,25 2006 | M1/DLPFC | 25 Hz | 100 MT | 18 000 (3000 × 6) | 4 wk | Coil back surface |
| Brusa et al,36 2006 | SMA | 1 Hz | 90 RMT | 9600 (1200 × 8) | 5 d | Tilted coil |
| del Olmo et al,31 2007 | DLPFC | 10 Hz | 90 RMT | 4500 (900 × 5) | 10 d | Tilted coil |
| Hamada et al,34 2008 | SMA | 5 Hz | 110 AMT | 4500 (450 × 10) | 8 wk | Realistic sham |
| Sedlácková et al,41 2009 | PMd/DLPFC | 10 Hz | 100 RMT | 8000 (1000 × 8) | 1 db | Occipital stimulation |
| Filipović et al,37,38 2009, 2010 | M1 | 1 Hz | Approximately 90 RMT | 1350 (1350 × 1) | 4 d | Sham coil |
| Pal et al,27 2010 | DLPFC | 5 Hz | 90 RMT | 7200 (1800 × 4) | 10 d | Tilted coil |
| Arias et al,23 2010 | Vertex | 1 Hz | 90 RMT | 6000 (600 × 10) | 10 d | Inactive and active coils |
| González-García et al,29 2011 | M1 | 25 Hz | 80 RMT | 1000 (100 × 10) | 12 wk | Occipital stimulation |
| Benninger et al,32 2012 | M1 | 50 Hz | 80 AMT | 30 000 (2000 × 15) | 2 wk | Inactive and active coils |
| Maruo et al,26 2013 | M1 | 10 Hz | 100 RMT | 4800 (600 × 8) | 3 d | Realistic sham |
| Shirota et al,30 2013 | SMA | 1 and 10 Hz | 110 RMT | 3000 (1000 × 3) | 8 wk | Realistic sham |
| Nardone et al,40 2014 | DLPFC | 1Hz | Below AMT | 8000 (1000 × 8) | 1 d | Sham coil |
Abbreviations: AMT, active motor threshold (MT); DLPFC, dorsolateral prefrontal cortex; M1, primary motor cortex; PMd, dorsal premotor cortex; RMT, resting MT; rTMS, repetitive transcranial magnetic stimulation; SMA, supplementary motor area.
a
Total number of pulses (number of pulses per session times number of sessions).
b
Treatment was 1 day for each region; these treatment days were separated by at least 1 day.