Table 3.
Characteristics of Included Studies: Outcome Measurements
| Source | On/Offa | Post-rTMS Evaluation |
rTMS Changeb | |
|---|---|---|---|---|
| Active | Sham | |||
| Siebner et al,42 2000 | Off | 1 h | −7.40 | −2.90 |
| Boylan et al,35 2001 | Off | Immediately | NA | NA |
| Shimamoto et al,28 2001 | On and off | Immediately | −8.35 | −0.80 |
| Khedr et al,24 2003 | Off | 1 h and 1 mo | −14.3 | −0.62 |
| Lefaucheur et al,39 2004 | Off | 20 min | −6.50 | −2.00 |
| Khedr et al,33 2006 | Off | Immediately | NA | NA |
| Lomarev et al,25 2006 | On and off | 1 d and 1 mo | −3.50 | 1.08 |
| Brusa et al,36 2006 | On | 1 h | −23.90 | −20.80 |
| del Olmo et al,31 2007 | On | 1 d | NA | NA |
| Hamada et al,34 2008 | On | 4 wk | −4.78 | 0.01 |
| Sedlácková et al,41 2009 | Off | Immediately | 0.05 | 0.80 |
| Filipović et al,37,38 2009, 2010 | On and off | 1 d | −1.75 | −1.40 |
| Pal et al,27 2010 | On | 1 d and 1 mo | −5.00 | −1.50 |
| Arias et al,23 2010 | On and off | Immediately and 1 wk | −6.78 | −3.83 |
| González-García et al,29 2011 | On | 15 min | −7.50 | −0.80 |
| Benninger et al,32 2012 | On and off | 1 d and 1 mo | −2.10 | −0.88 |
| Maruo et al,26 2013 | Off | 1 h | −5.90 | −0.40 |
| Shirota et al,30 2013 | On | 1 and 12 wk | −3.91 | −3.20 |
| Nardone et al,40 2014 | On | 1, 12, and 24 h | −1.17 | −0.75 |
Abbreviations: NA, not available; rTMS, repetitive transcranial magnetic stimulation.
a
Medication state during assessment.
b
Changes in the motor section of the Unified Parkinson’s Disease Rating Scale-III score (post-rTMS score minus pre-rTMS score). More negative values (ie, greater decrements in the score) represent greater improvement in motor symptoms following rTMS sessions.