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. 2015 Jan 13;24(10):1182–1193. doi: 10.1089/scd.2014.0486

FIG. 2.

FIG. 2.

MSCs and GFs modified radiation-induced collagen deposition. (A) Representative macroscopic pictures, (B) Masson trichrome staining in irradiated groups, MSC-treated groups, and GF-treated groups on days 28 and 50 after irradiation. ×20 magnification. (C) Staining revealed a high density of dermal collagen fibers with unidirectional alignment parallel to the white arrows after irradiation and the restoration of multidirectional alignment after MSC or GF treatment. (D) Real-time PCR of Col3a, Col1a, and Col1a/Col3a ratio. Data are expressed relative to control mice and normalized to GAPDH. Results are expressed as mean±SEM. P values were calculated by analysis of variance (ANOVA) with Bonferroni correction, *P<0.05; **P<0.01 compared with nonirradiated controls; #P<0.05; ##P<0.01 compared with irradiated-untreated controls.