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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Mol Nutr Food Res. 2015 Mar 17;59(5):991–999. doi: 10.1002/mnfr.201400761

Figure 4. Aging was associated with increased ICAM1 and IL6 gene expression and decreased IL6 promoter methylation.

Figure 4

(A) Plasma zinc concentrations in young (2 mo) and aged (26 mo) mice (n=6 per group). Data represent mean ± SEM. *P < 0.05 vs. young. (B) ICAM1 and IL6 gene expression in the spleens of young (2mo) and aged (26mo) mice (n=6 per group). Data represent mean normalized fold-change ± SEM vs. young. *P < 0.01 vs. young. (C) IL6 promoter methylation in the spleens of young (2mo) and aged (26mo) mice (n=6 per group). Data represent mean methylation percentage ± SEM. *P < 0.01 vs. young. (D) IL6 promoter methylation in human lymphoblastic cell lines derived from young (20–28 yr) and aged (92–101 yr) individuals represented as box and whiskers plot (n=10 per group). Whiskers represent maximum and minimum values.

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