Table 3.

Glutamate-modulating pharmacotherapy for attention deficit hyperactivity disorder

Medication	Author	Year	Duration	N	Results
Amantadine	Mattes186	1980	1 month	8	Improvement on 100 mg/day
	Donfrancesco187	2007	6 weeks	24	Improvement on 50–150 mg/day
	Mohammadi188	2010	6 weeks	28	Limited improvement on 100–150 mg/day
Lamotrigine	Öncü189	2014	48 months	40	Improvement on 25–250 mg/day
Memantine	Findling193	2007	8 weeks	16	Improvement on 10–20 mg/day
	Surman194	2013	12 weeks	28	Improvement on 10 mg/day
NAC	Garcia195	2013	3 months	49	Improvement on 2.4–4.8 g/day

Abbreviations: N, number of patients; NAC, N-acetylcysteine.