Table 4.

Glutamate-modulating pharmacotherapy in grooming disorders and OCD-related disorders

Medication	Author	Year	Duration	N	Results
NAC	Grant163	2009	12 weeks	50	Improvement on 1.2–2.4 g/day (TTM)
	Rodrigues-Barata156	2012	2–6 months	2	Improvement on 1,200 mg/day (TTM)
	Taylor150	2014	10 weeks	1	Improvement on 1,200 mg/day (TTM)
	Bloch155	2013	12 weeks	39	Limited improvement on 1,200 mg twice daily (TTM)
	Odlaug210	2007	2 weeks	5	Improvement on 1,800 mg/day (ExD and TTM)
	Miller175	2014	12 weeks	35	Improvement on 450–1,200 mg/day (ExD)
Lamotrigine	Grant211	2007	12 weeks	24	Improvement on 25–300 mg/day (ExD)
	Grant162	2010	12 weeks	29	Limited improvement on 12.5–300 mg/day (ExD)
Topiramate	Lochner212	2006	16 weeks	9	Improvement on 50–250 mg/day (TTM)
	Shapira213	2002	8 weeks	3	Improvement on 50–150 mg/day augmentation (ExD)
	Jafferany214	2010	12 weeks	2	Improvement on 200 mg/day augmentation (ExD)
Riluzole	Coric215	2007	3 months	1	Improvement on 100 mg/day augmentation for fluoxetine (ExD)

Abbreviations: OCD, obsessive–compulsive disorder; N, number of patients; NAC, N-acetylcysteine; TTM, trichotillomania; ExD, excoriation disorder.