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. Author manuscript; available in PMC: 2015 May 8.
Published in final edited form as: Expert Rev Vaccines. 2009 Sep;8(9):1251–1276. doi: 10.1586/erv.09.77

Table 6.

Commercial and DNA rabies vaccines.

Vaccine Vector Dosage Price Vaccination
ages		 Protection Ref.
Rabvac™
(Fort Dodge,
KS, USA)		 Killed virus
with adjuvant		 One 1-ml dose sc. or im.
Revaccinate 1 year later
and every 3 years
thereafter		 US$74.99/50
doses ($1.50/
dose)		 3 months Dogs, cats and horses
Neutralizing antibodies in dogs
within 2 months, 100% against
lethal challenge		 [20]
Defensor 3®
(Pfizer, NY,
USA)		 Chemically
inactivated rabies
virus with adjuvant		 One 1-ml dose sc.
Revaccinate 1 year later and
every 3 years thereafter		 US$21.95/ten
doses (US$2.20/
dose)		 3 months Dogs, cats, sheep and cattle,
but extends to raccoons
and bats
Prorab®
(Intervet, The
Netherlands)		 Killed virus
with adjuvant		 One 1-ml dose sc. or im.
with annual revaccination		 US$13.85/ten
doses (US$1.39/
dose)		 3 months Dogs, cats and sheep
Imrab®
(Merial
Animal
Health Ltd,
UK)		 Inactivated
rabies virus		 One 1-ml dose sc. or im.
Revaccinate 2 year later
and every 3 years
thereafter		 US$102.97/50
doses
(US$2.06/dose)		 3 months Cats, dogs, sheep, cattle,
horses and ferrets
Virus-neutralizing antibodies
Raboral
V-RG®
(Merial
Animal
Health Ltd)		 Nonpathogenic
virus with small
portion of viral
RNA encoding
G protein of the
rabies virus		 2 ml of vaccine in fish
meal or dog food bait		 US$1.30/
vaccine-bait unit		 For adult wild
animals		 Protects coyotes and raccoons
within 14 days
DNA vaccine
(Tesoro-Cruz
et al. 2008)		 Plasmid encoding
glycoprotein of
rabies virus		 100 µg of DNA im.,
intranasally and
intradermally with
booster 30 days later		 Unknown 1–2 years Neutralizing antibodies in cats
within 15 days and in mice via
passive transfer of cat sera/
antibodies. 100% protection in
mice. Protection from lethal
challenge for cats (100% for
intradermal vaccination and
67% for im. route)		 [91]
DNA vaccine
(Lodmell
et al. 2006)		 Plasmid encoding
glycoprotein of
rabies virus		 100-µg DNA
intradermally in ear
Pinnae		 Unknown 12–14 months Neutralizing antibodies within
2 months in dogs, persisting for
6 months. 100% protection
against lethal challenge		 [20]

im.: Intramuscular; sc.: Subcutaneous.