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. Author manuscript; available in PMC: 2015 May 8.
Published in final edited form as: Expert Rev Vaccines. 2009 Sep;8(9):1251–1276. doi: 10.1586/erv.09.77

Table 8.

Treatment options for canine oral melanoma.

Treatment Dosing/administration Cost/availability Results Ref.
Surgery Excision surgery and biopsy ~US$3000 MST of 17–18 months for stage I (<2 cm
diameter tumor), 5–6 months for stage II
(2–4 cm diameter tumor) and 3 months for
stage III (>4 cm diameter tumor)		 [95]
Radiation therapy Total dose of 24 Gy over three doses
36 Gy in varying doses		 ~US$2000 53% complete remission, 30%
partial remission, MST of 7 months		 [92,93]
Chemotherapy Carboplatin administered at doses of
300 or 350 mg/m2 of body surface area		 US$3000–4000
(carboplatin is
US$1.90–1.95/mg)		 28% overall response rate, 24% partial
response rate, MST of 165 days		 [94]
Merial DNA
vaccine (Merial
Animal Health
Ltd, UK)		 Administered after surgical excision
of tumor
Four 0.4-ml doses administered
transdermallly biweekly. Booster dose
every 6 months thereafter		 Available to
board-certified
veterinary
oncologists
US$500/dose		 MST of 569 days (19 months) for
stage ll–lll dogs		 [96]

MST: Mean survival time.