Table 4. Association between finasteride concentrations and genes in metabolism and target pathways among white men. # .
| Gene | SNP | Genotype | N | % Frequency | Finasteride (ng/mL) | p-trend * |
|---|---|---|---|---|---|---|
| Mean (SD) | ||||||
| CYP3A4 | rs2242480 | CC | 823 | 85.6 | 30.30 (19.53) | 0.004 |
| CT | 130 | 13.5 | 26.21 (17.09) | |||
| TT | 8 | 0.8 | 15.07 (8.00) | |||
| rs2740574 | AA | 912 | 93.7 | 29.90 (19.51) | 0.060 | |
| AG | 59 | 6.1 | 26.45 (14.65) | |||
| GG | 2 | 0.2 | 13.62 (15.81) | |||
| rs4646437 | CC | 801 | 83.3 | 30.35 (19.69) | 0.002 | |
| CT | 149 | 15.5 | 26.48 (17.18) | |||
| TT | 12 | 1.2 | 16.85 (7.46) | |||
| rs4986907 | GG | 973 | 100.0 | 29.62 (19.24) | NA | |
| rs4986910 | AA | 953 | 98.6 | 29.46 (19.21) | 0.005 | |
| (M445T) | AG | 14 | 1.4 | 43.28 (20.30) | ||
| CYP3A5 | rs15524 | CC | 6 | 0.6 | 17.17 (8.70) | 0.006 |
| CT | 121 | 12.5 | 25.73 (14.01) | |||
| TT | 842 | 86.9 | 30.26 (19.90) | |||
| rs28365085 | TT | 723 | 100.0 | 30.04 (19.27) | NA | |
| rs776746 | AA | 5 | 0.5 | 17.21 (9.72) | 0.001 | |
| AG | 111 | 11.7 | 24.58 (14.12) | |||
| GG | 832 | 87.8 | 30.34 (19.82) | |||
| SRD5A2 | rs11675297 | AA | 3 | 0.3 | 49.30 (11.95) | 0.866 |
| AG | 60 | 6.3 | 28.81 (22.57) | |||
| GG | 888 | 93.4 | 29.61 (19.07) | |||
| rs2300700 | AA | 205 | 21.5 | 28.35 (18.27) | 0.083 | |
| AG | 477 | 50.1 | 29.16 (19.92) | |||
| GG | 271 | 28.4 | 31.70 (18.90) | |||
| rs4952197 | AA | 78 | 8.1 | 31.93 (17.42) | 0.850 | |
| AG | 369 | 38.3 | 28.58 (18.31) | |||
| GG | 517 | 53.6 | 30.06 (20.18) | |||
| rs523349 | CC | 394 | 41.8 | 30.16 (20.18) | 0.790 | |
| (V89L) | CG | 466 | 49.5 | 28.85 (18.99) | ||
| GG | 82 | 8.7 | 30.88 (17.17) | |||
| rs6732223 | CC | 240 | 26.0 | 32.16 (19.11) | 0.104 | |
| CT | 468 | 50.8 | 28.28 (18.47) | |||
| TT | 214 | 23.2 | 28.97 (19.15) | |||
| rs6760199 | AA | 77 | 8.0 | 32.56 (17.39) | 0.920 | |
| AC | 380 | 39.3 | 28.75 (18.27) | |||
| CC | 511 | 52.8 | 29.88 (20.19) | |||
| rs9282858 | AG | 64 | 8.9 | 28.09 (18.83) | 0.630 | |
| (A49T) | GG | 659 | 91.1 | 30.27 (19.47) | ||
| rs9332975 | AA | 778 | 80.3 | 29.10 (19.35) | 0.120 | |
| AG | 181 | 18.7 | 31.52 (18.82) | |||
| GG | 10 | 1.0 | 33.19 (22.28) | |||
| Gene | SNP | Genotype | N | % Frequency | Finasteride (ng/mL) | p-trend * |
| Mean (SD) | ||||||
| SRD5A2L | rs10001607 | CC | 292 | 30.6 | 29.15 (20.13) | 0.950 |
| (SRD5A3) | CT | 466 | 48.8 | 30.00 (18.40) | ||
| TT | 196 | 20.5 | 28.99 (18.67) | |||
| rs11133373 | CC | 449 | 46.4 | 29.62 (17.68) | 1.000 | |
| CG | 433 | 44.7 | 29.73 (20.42) | |||
| GG | 86 | 8.9 | 29.51 (21.41) | |||
| rs7663650 | CC | 400 | 41.3 | 30.23 (18.88) | 0.480 | |
| CT | 465 | 48.0 | 28.98 (19.49) | |||
| TT | 103 | 10.6 | 29.59 (19.98) | |||
| rs7682870 | AA | 588 | 60.9 | 29.72 (19.66) | 0.890 | |
| AC | 336 | 34.8 | 29.07 (18.82) | |||
| CC | 41 | 4.2 | 31.67 (16.25) | |||
| rs819270 | AA | 92 | 9.6 | 32.84 (22.29) | 0.120 | |
| AG | 388 | 40.3 | 29.77 (18.17) | |||
| GG | 483 | 50.2 | 28.81 (19.47) |
# Treatment compliant men in the PCPT finasteride arm.