Skip to main content
. 2015 May 8;10(5):e0123478. doi: 10.1371/journal.pone.0123478

Fig 6. Berberin inhibits CRC cell migration and invasion through COX-2/PGE2-JAK2/STAT3 mediated signaling pathway.

Fig 6

A. and B. Extracts from SW620 cells treated with AZD1480 for 2 h, transfected with COX-2 over-expression construct for 24 h, treated with berberin (40 μM) for 48 h, were analyzed for pJAK2, JAK2, pSTAT3, STAT3, MMP-2, MMP-9 and beta-actin. C. and D. Extracts from SW620 cells treated with AZD1480 for 2 h, treated with berberin (40 μM) or PGE2 (5 μM) for 48 h, were analyzed for pJAK2, JAK2, pSTAT3, STAT3, MMP-2, MMP-9 and beta-actin.