Table 4.

Associations Between Regional Adipose Tissue, Adipocytokines and Neuropsychiatric Test Scores After Controlling for HIV-Specific Factors

Controlled for demographics* and HIV-specific factors**:	VAT	aSAT	tSAT	adiponectin	leptin	IL-6	hs-CRP
TA	0.98 (0.55)	0.98 (0.67)	0.98 (0.73)	1.10 (0.13)	1.02 (0.37)	1.07 (0.09)	1.02 (0.65)
TB	1.00 (0.94)	1.10 (0.13)	1.07 (0.19)	1.10 (0.20)	1.07 (0.11)	1.07 (0.17)	1.00 (0.82)
SymD	1.74 (0.37)	−0.54 (0.77)	−1.91 (0.18)	−5.59 (<0.01)	−2.00 (0.18)	−3.33 (0.07)	−1.81 (0.19)

Note 1: For TA and TB, beta estimates <1 indicate better performance. For SymD, beta estimates >1 indicate better performance.

Note 2: No interaction was observed between adipose tissue depots.

^**Includes age, race, and education

^**HIV-specific factors=Current antiretroviral therapy (ART), current CD4 T cell count and nadir CD4 T cell count. Inclusion of years on ART, HIV-1 viral load, and/or history of AIDS diagnosis did not improve model fit. When CD4 count stratified by <200, <500, or >500 cells/μL, significant effect of CD4<500 cells/μL found for Trails A only. CD4-by-age interaction existed for current CD4<200 cells/μL.

TA=Trails A, TB=Trails B, SymD=symbol-digit, VAT=visceral adipose tissue, aSAT=abdominal subcutaneous adipose tissue, tSAT=thigh subcutaneous adipose tissue, IL-6=interleukin-6, hs-CRP=high-sensitivity C-reactive protein