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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Kidney Int. 2015 Jan 7;87(5):948–962. doi: 10.1038/ki.2014.386

Figure 1. Loss of p47phox improves adriamycin-mediated albuminuria.

Figure 1

Kidney injury was induced by a single tail vein injection of adriamycin (10 mg/Kg b.w.) in wild type (WT), integrin α1KO, p47phoxKO, integrin α1KO/p47phoxKO (DKO) mice and changes in body weight (A) and urine albuminuria (B, C) were examined over time. (*) indicates significant differences (p≤0.05) between α1KO and WT, or α1KO and p47phoxKO, or α1KO and DKO. Values are the mean ± SD of the number of mice indicated. (B) SimplyBlue staining of 1 μl urine showing elevated albuminuria in adriamycin-treated integrin α1KO mice compared to WT, p47phoxKO or DKO mice. Alb = mouse serum albumin (1.25 μg/lane). (C) Urine albumin excretion expressed as albumin-to-creatinine ratio (ACR) in untreated or adriamycin-treated WT, α1KO, p47phoxKO, and DKO mice. Values represent the mean ± SD of the mice indicated. Difference between injured WT and α1KO (*) or injured WT and p47phoxKO (**) or injured α1KO and DKO (δ) mice were significant (p≤0.05).